Perturbation Impact on HBB Gene Scores

§ Widget · 06 Perturbation Impact on HBB Gene Scores

Comparing per-position scores before and after introducing a 30bp perturbation (positions 750–780) in the human hemoglobin beta (HBB) gene sequence. The original sequence shows baseline model predictions, while the perturbed version reveals how local sequence changes propagate through the model's scoring. Blue-highlighted regions mark the three coding sequence (CDS) exons. The visualization demonstrates both local effects within the perturbed region and potential downstream impacts on score distributions across the gene.

          Score Difference (Original - Perturbed)
        

Original Scores

Perturbed Scores

Score Difference

CDS regions

Perturbed region (750-780)